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1x di2 Time trial/triathlon setup

Hello everyone, I was wondering what problems I should look out for if I were to set up a tt bike with: a single 50t chain ring a shimano grx long cage derailleur with an 11-40 cassette.

Just thinking I could do this with an older tt frame I had and could save some money and weight on shifters and derailleurs.

Is this crazy or doable. Would I worry about the rear derailleur next to the spokes or would the grx derailleur cope with it?

Many thanks in advance

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